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Pigmented choroid plexus papilloma
E L Reimund1, J E Sitton, J C Harkin
1Department of Pathology, Tulane University School of Medicine, New Orleans, LA 70112.
Archives of Pathology & Laboratory Medicine
|August 1, 1990
Summary
This study reports the first case of a pigmented choroid plexus papilloma containing neuromelanin and lipofuscin in a young patient with a history of seizures. The rare tumor presented unique pigment characteristics.
Area of Science:
- Neuropathology
- Pediatric Oncology
- Neuroscience
Background:
- Choroid plexus papillomas are rare tumors typically found in the lateral ventricles.
- While generally benign, they can cause significant neurological symptoms, including seizures.
- Pigmentation in these tumors is uncommon and not well-characterized.
Observation:
- A 15-year-old male presented with a 10-year history of seizures.
- Imaging revealed a lesion in the left lateral ventricle.
- Gross examination showed a finely lobular, orangish-brown, rubbery, gritty, and friable mass.
Findings:
- Microscopic analysis confirmed a choroid plexus papilloma with papillary formations and fibrovascular cores.
- Light and electron microscopy revealed neoplastic cells containing both neuromelanin and lipofuscin pigment.
- This represents the first documented instance of neuromelanin within a choroid plexus papilloma.
Implications:
- The presence of neuromelanin in this tumor offers new insights into the cellular origins and differentiation of choroid plexus tumors.
- Understanding the pigment composition may aid in future diagnostic approaches and differential diagnoses.
- This case highlights the diverse histological and ultrastructural features that can occur in pediatric central nervous system tumors.