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Pigmented choroid plexus papilloma.

E L Reimund1, J E Sitton, J C Harkin

  • 1Department of Pathology, Tulane University School of Medicine, New Orleans, LA 70112.

Archives of Pathology & Laboratory Medicine
|August 1, 1990
PubMed
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This study reports the first case of a pigmented choroid plexus papilloma containing neuromelanin and lipofuscin in a young patient with a history of seizures. The rare tumor presented unique pigment characteristics.

Area of Science:

  • Neuropathology
  • Pediatric Oncology
  • Neuroscience

Background:

  • Choroid plexus papillomas are rare tumors typically found in the lateral ventricles.
  • While generally benign, they can cause significant neurological symptoms, including seizures.
  • Pigmentation in these tumors is uncommon and not well-characterized.

Observation:

  • A 15-year-old male presented with a 10-year history of seizures.
  • Imaging revealed a lesion in the left lateral ventricle.
  • Gross examination showed a finely lobular, orangish-brown, rubbery, gritty, and friable mass.

Findings:

  • Microscopic analysis confirmed a choroid plexus papilloma with papillary formations and fibrovascular cores.
  • Light and electron microscopy revealed neoplastic cells containing both neuromelanin and lipofuscin pigment.

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  • This represents the first documented instance of neuromelanin within a choroid plexus papilloma.

    • Implications:

    • The presence of neuromelanin in this tumor offers new insights into the cellular origins and differentiation of choroid plexus tumors.
    • Understanding the pigment composition may aid in future diagnostic approaches and differential diagnoses.
    • This case highlights the diverse histological and ultrastructural features that can occur in pediatric central nervous system tumors.