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Updated: May 28, 2026

Pyrosequencing: A Simple Method for Accurate Genotyping
13:06

Pyrosequencing: A Simple Method for Accurate Genotyping

Published on: January 8, 2008

Practical tools to implement massive parallel pyrosequencing of PCR products in next generation molecular diagnostics

Kim De Leeneer1, Joachim De Schrijver, Lieven Clement

  • 1Center for Medical Genetics, Ghent University, Ghent, Belgium. Kim.deleeneer@UGent.be

Plos One
|October 8, 2011
PubMed
Summary

Massively parallel sequencing (MPS) enables multigenic disorder diagnostics. This study provides practical strategies, coverage requirements, and tools to optimize MPS for reliable molecular diagnostics in patient cohorts.

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.