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Multifractal spectrum of chorionic villi: a novel approach
1Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. deypranab@hotmail.com
Objective:
To measure the multifractal dimension in histopathology sections of chorionic villi to study its role to distinguish between normal chorionic villi and hydatidiform mole.
Study Design:
Multifractal spectrum was measured in 10 each cases of normal chorionic villi and hydatidiform mole. The values of alpha max and alpha min and their difference Delta alpha (alpha max--alpha min) were recorded in each case. The data for these groups were compared.
Results:
The mean +/- SD of alpha max, alpha min, and Delta alpha (alpha max--alpha min) of normal chorionic villi were 2.6335 +/- 0.16109, 1.6975 +/- 0.04435, and 0.9360 +/- 0.12725, respectively. Whereas the mean +/- SD of alpha max, alpha min, and Delta of hydatidiform moles were 2.3196 +/- 0.11937, 1.6209 +/- 0.06208, and 0.7000 +/- 0.08350, respectively. The mean alpha max, alpha min, and Delta alpha of normal chorionic villi were much higher than for hydatidiform mole. Independent sample t-test shows significant difference (p < 0.001) in alpha max, alpha min, and Delta alpha of normal chorionic villi and hydatidiform mole.
Conclusion:
Multifractal dimension was significantly different in normal chorionic villi and hydatidiform mole.

