Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TDCPP induces ferroptosis in THP-1 macrophages through mitochondrial regulation of Fe<sup>2 +</sup> homeostasis.

Ecotoxicology and environmental safety·2026
Same author

Autophagy in thyroid cancer: Immune suppression and drug resistance.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2026
Same author

Retraction notice to "Gene regulation by antisense transcription: A focus on neurological and cancer diseases" [Biomedicine & Pharmacotherapy 145 (2022) 112265].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

DP103 as a critical modulator of Wnt signaling and cancer stemness: implications for precision treatment in triple negative breast cancer.

Cell death & disease·2026
Same author

Retraction notice to "New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities" [Biomedicine & Pharmacotherapy 141 (2021) 111824].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Autophagy as a therapeutic linchpin in metabolic diseases and obesity-associated diabetes.

Autophagy·2026

Related Experiment Video

Updated: May 28, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Multifaceted link between cancer and inflammation.

Gautam Sethi1, Muthu K Shanmugam, Lalitha Ramachandran

  • 1Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. gautam_sethi@nuhs.edu.sg

Bioscience Reports
|October 11, 2011
PubMed
Summary
This summary is machine-generated.

Chronic inflammation is a key driver of cancer initiation and progression. Understanding the molecular mechanisms linking inflammation to cancer is crucial for developing new therapeutic strategies.

More Related Videos

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Related Experiment Videos

Last Updated: May 28, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Chronic inflammation is increasingly recognized as a significant factor in the development of numerous chronic diseases, particularly cancer.
  • Epidemiological, preclinical, and clinical studies provide substantial evidence linking inflammatory responses to cancer initiation and progression.

Purpose of the Study:

  • To review the molecular mechanisms through which chronic inflammation contributes to cancer.
  • To elucidate the critical link between inflammatory mediators and tumor development, progression, and resistance to therapies.

Main Methods:

  • This review synthesizes findings from epidemiological, preclinical, and clinical studies.
  • It focuses on the role of specific inflammatory mediators and transcription factors involved in cancer.

Main Results:

  • Dysregulated inflammatory responses increase the production of pro-inflammatory mediators (cytokines, chemokines, reactive oxygen intermediates).
  • Key molecular players include COX-2, 5-LOX, MMPs, NF-κB, STAT3, AP-1, and HIF-1α, which promote tumor cell proliferation, metastasis, and resistance.
  • Environmental and lifestyle factors (infections, tobacco, diet, obesity, alcohol) activate these inflammation-associated molecules, contributing to up to 90% of cancers.

Conclusions:

  • Inflammation is a critical factor in the initiation and progression of cancer.
  • Understanding these molecular links is essential for targeted cancer prevention and treatment strategies.