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Related Concept Videos

Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...
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Related Experiment Video

Updated: May 28, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Bilateral uveitis associated with fluoroquinolone therapy.

David M Hinkle1, Mark S Dacey, Efrem Mandelcorn

  • 1MERSI, 5, Cambridge Center, 8th Floor, Cambridge, NY 02142, USA. dmh15@case.edu

Cutaneous and Ocular Toxicology
|October 11, 2011
PubMed
Summary

A possible link between fluoroquinolone antibiotics and uveitis, an inflammatory eye condition, was identified in 40 case reports. Clinicians should monitor for this adverse drug reaction, especially bilateral cases with iris transillumination.

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Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging
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Related Experiment Videos

Last Updated: May 28, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
10:33

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Published on: December 17, 2021

Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging
07:39

Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging

Published on: June 14, 2021

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Drug Safety

Background:

  • Systemic fluoroquinolone use is common for various infections.
  • Uveitis is a serious ocular inflammatory condition.
  • The potential for drug-induced ocular side effects necessitates ongoing research.

Observation:

  • Forty case reports of uveitis associated with systemic fluoroquinolone therapy were reviewed.
  • The median age of affected patients was 54 years, with a median onset of 13 days after therapy initiation.
  • Positive dechallenge was noted in five cases, suggesting a potential causal link.

Findings:

  • A possible association between fluoroquinolone use and uveitis was identified, meeting World Health Organization criteria.
  • Bilateral uveitis, iris transillumination, and pigment dispersion were noted in some cases.
  • The median time to adverse drug reaction (ADR) onset was 13 days.

Implications:

  • Clinicians should maintain a high index of suspicion for fluoroquinolone-associated uveitis.
  • Awareness of this ADR is crucial for timely diagnosis and management.
  • Further investigation into the mechanisms of fluoroquinolone-induced uveitis is warranted.