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Updated: May 28, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
A diruthenium catalyst for selective, intramolecular allylic C-H amination: reaction development and mechanistic
Mark Edwin Harvey1, Djamaladdin G Musaev, J Du Bois
1Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Abstract:
The mixed-valent paddlewheel complex tetrakis(2-oxypyridinato)diruthenium(II,III) chloride, [Ru(2)(hp)(4)Cl], catalyzes intramolecular allylic C-H amination with bis(homoallylic) sulfamate esters. These results stand in marked contrast to reactions performed with dirhodium catalysts, which favor aziridine products. The following discussion constitutes the first report of C-H amination using complexes such as [Ru(2)(hp)(4)Cl] and related diruthenium adducts. Computational and experimental studies implicate a mechanism for [Ru(2)(hp)(4)Cl]-promoted C-H amination involving hydrogen-atom abstraction/radical recombination and the intermediacy of a discrete, albeit short-lived, diradical species. The collective data offer a coherent model for understanding the preference of this catalyst to oxidize allylic (and benzylic) C-H bonds.
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