Adult neurogenesis and acupuncture stimulation at ST36

Although it was believed that the brain was incapable of regeneration after embryonic development, neurogenesis is now known to occur into adulthood. Adult neurogenesis has been demonstrated in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus. Acupuncture has long been used to treat neurologic conditions, and recent reports suggest that neurogenesis may account for its beneficial effects. ST36 was the most often used acupoint in previous reports and was shown to enhance cell proliferation and neuronal differentiation. This acupoint may be linked to the brain through the primo vascular system, an anatomic structure thought to correspond to acupuncture meridians. This primitive vascular-like system appears to be involved in physiologic and pathologic processes by circulating substances throughout the body. The role of the primo vascular system as the link between the skin and brain underlying the beneficial effects of acupuncture requires further investigation.