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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

[Nephroprotection, fact or fiction?]

Thierry Krummel1, Anne-Laure Faller, Dorothée Bazin

  • 1Hôpitaux universitaires de Strasbourg, service de néphrologie, 67792 Strasbourg cedex, France. thierry.krummel@chru-strasbourg.fr

Presse Medicale (Paris, France : 1983)
|October 11, 2011
PubMed

Insights

Pharmacological interventions slow chronic kidney disease progression, with renin-angiotensin system blockers being key. Nephroprotection is linked to reduced proteinuria and individualized blood pressure targets.

Area of Science:

  • Nephrology
  • Pharmacology

Context:

  • Recent clinical studies highlight pharmacological interventions for chronic kidney disease (CKD) management.
  • The concept of nephroprotection is established, emphasizing slowing disease progression.

Purpose:

  • To review the benefits and limitations of pharmacological interventions in CKD.
  • To discuss the role of renin-angiotensin system (RAS) blockers and blood pressure targets in nephroprotection.

Summary:

  • Renin-angiotensin system blockers are central to nephroprotective strategies, with efficacy correlating to proteinuria reduction.
  • Combination therapy with ACE inhibitors (ACEI) and angiotensin II receptor antagonists (ARA) is not routinely recommended.
  • Individualized blood pressure targets are crucial, especially in type 2 diabetic nephropathy, balancing renal and cardiovascular risks.
  • Correction of metabolic acidosis with sodium bicarbonate also demonstrates nephroprotective effects.

Impact:

  • Provides an updated overview of evidence-based nephroprotective treatments.
  • Informs clinical practice regarding RAS blockade, combination therapies, and blood pressure management in CKD.
  • Highlights emerging nephroprotective strategies like metabolic acidosis correction.

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