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Updated: May 28, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

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[Hyperhomocysteinemia and schizophrenia: case control study].

H Mabrouk¹, W Douki, A Mechri

¹Laboratoire de biochimie-toxicologie, hôpital universitaire Fattouma Bourguiba, 5000 Monastir, Tunisie. hajer mabrouk@yahoo.fr

|October 11, 2011

Summary

This summary is machine-generated.

Elevated homocysteine (Hcys) and low folate levels are common in schizophrenia patients. Higher Hcys is linked to no family psychiatric history and lower vitamin B12, suggesting a role in schizophrenia.

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Area of Science:

Neuroscience
Biochemistry
Psychiatry

Context:

Schizophrenia is a complex neuropsychiatric disorder.
Elevated homocysteine (Hcys) levels are implicated in schizophrenia.
Low folate and vitamin B12 may contribute to increased Hcys.

Purpose:

Determine plasma Hcys, folate, and vitamin B12 levels in schizophrenia patients.
Assess the frequency and severity of hyperhomocysteinemia.
Investigate associations between Hcys, clinical features, and nutrient levels.

Summary:

Schizophrenia patients exhibited higher plasma Hcys and lower folate than controls.
Hyperhomocysteinemia was more prevalent in patients (34.4%) vs. controls (15.2%).
Plasma Hcys correlated negatively with vitamin B12 and was higher in patients without a family psychiatric history.

Impact:

Confirms elevated Hcys in schizophrenia.
Suggests Hcys is linked to absence of family psychiatric history and low vitamin B12.
Highlights Hcys as a potential factor in schizophrenia pathophysiology and management.