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Analysis of Hematopoietic Stem Progenitor Cell Metabolism
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Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Toshio Suda1, Keiyo Takubo, Gregg L Semenza

  • 1Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. sudato@sc.itc.keio.ac.jp

Cell Stem Cell
|October 11, 2011
PubMed

Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaerobic metabolism by maintaining a high rate of glycolysis. This metabolic balance promotes HSC maintenance by limiting the production of reactive oxygen species, but leaves HSCs susceptible to changes in redox status. In this review, we discuss the importance of oxygen homeostasis and energy metabolism for maintenance of HSC function and long-term self-renewal.

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