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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: May 28, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Ab interno trabeculectomy versus trabeculectomy for open-angle glaucoma.

Seung Youn Jea1, Brian A Francis, Ghazal Vakili

  • 1Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.

Ophthalmology
|October 11, 2011
PubMed
Summary

Ab interno trabeculectomy showed a lower success rate compared to traditional trabeculectomy for open-angle glaucoma. Further glaucoma surgery was needed more often after ab interno trabeculectomy.

Related Experiment Videos

Last Updated: May 28, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Glaucoma Research

Background:

  • Open-angle glaucoma management often requires surgical intervention when medical therapy fails.
  • Trabeculectomy is a traditional surgical procedure for lowering intraocular pressure (IOP).
  • Ab interno trabeculectomy represents a newer surgical approach.

Purpose of the Study:

  • To compare the efficacy and outcomes of ab interno trabeculectomy versus traditional trabeculectomy.
  • Evaluate success rates, intraocular pressure reduction, and complication rates between the two surgical methods.

Main Methods:

  • Retrospective cohort study comparing 115 patients undergoing ab interno trabeculectomy with 102 patients undergoing trabeculectomy.
  • Inclusion criteria: open-angle glaucoma, age ≥ 40, uncontrolled IOP on maximal medical therapy.
  • Primary outcome: success defined by IOP control, reduction, or need for further surgery; secondary outcomes: medication use and complications.

Main Results:

  • Mean follow-up was approximately 26 months.
  • Trabeculectomy achieved a higher success rate (76.1%) at 2 years compared to ab interno trabeculectomy (22.4%).
  • Ab interno trabeculectomy group required more subsequent glaucoma surgeries (43.5% vs 10.8%) and had a higher complication rate excluding hyphema.

Conclusions:

  • Ab interno trabeculectomy demonstrated a significantly lower success rate than traditional trabeculectomy in this cohort.
  • Trabeculectomy remains a more effective initial surgical procedure for achieving long-term IOP control in open-angle glaucoma.