Related Experiment Video
Updated: May 28, 2026

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput
Published on: September 22, 2019
9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp
Daowan Lai1, Shanjiang Yu, Leen van Ofwegen
1State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China.
Abstract:
Fourteen new 9,10-secosteroids designated as astrogorgols A-N (1-14) were isolated from a Chinese gorgonian Astrogorgia sp. together with eight known analogues. The structural patterns were characterized by the presence of a sterol-based 9,10-seco nucleus containing a 3-hydroxy-10-methylphenyl ring. Astrogorgol N (14) possessing a 1,4-dien-3-one unit in ring A was biogenetically considered as an intermediate to generate diverse 9,10-secosteroids. Five compounds showed significant inhibitory activities against human tumor related protein kinases, including ALK, AXL, FAK, IGF-1R, MET wt, SRC, and VEGF-R2.
Related Concept Videos
Anthelminthic Agents
Antifungal Agents
Activation and Inactivation of G Proteins