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A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

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Perinatal asphyxia: kidney failure does not affect S100B urine concentrations.

Francesco M Risso¹, Laura D Serpero, Luc J I Zimmermann

¹Department of Neonatology Obstetrics and Neuroscience, G Gaslini Children's University Hospital, Genoa, Italy.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|October 11, 2011

Summary

This summary is machine-generated.

Urine S100B protein reliably indicates brain damage in newborns, even with impaired kidney function. This study confirms its accuracy for monitoring newborns with perinatal asphyxia (PA).

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Area of Science:

Biochemistry
Neonatal Medicine
Clinical Chemistry

Background:

S100B protein is a recognized biomarker for brain damage.
Urine S100B assessment offers a non-invasive, repeatable method for newborns.
Kidney function can influence S100B levels, potentially affecting its reliability.

Purpose of the Study:

To investigate if kidney function affects urine S100B concentrations in newborns.
To determine the reliability of urine S100B as a brain damage marker in perinatal asphyxia (PA).

Main Methods:

Assessed urine S100B and kidney function (urea, creatinine, urine gravity) in healthy and asphyxiated newborns.
Utilized multiple logistic regression analysis to correlate S100B levels with clinical and laboratory parameters.

Main Results:

Urine S100B levels were significantly higher in newborns with PA.
No significant correlation was found between urine S100B and kidney function parameters.
S100B levels strongly correlated with the occurrence of PA.

Conclusions:

Altered kidney function does not confound urine S100B assessment in newborns.
Urine S100B is a reliable marker for brain injury, even in the context of kidney issues.
Supports the use of urine S100B for longitudinal monitoring of brain health in neonates.