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Published on: April 21, 2016
14-3-3 proteins as potential therapeutic targets
Jing Zhao1, Cheryl L Meyerkord, Yuhong Du
1Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA. zhaojing@fmmu.edu.cn
Seminars in Cell & Developmental Biology
|October 11, 2011
Summary
14-3-3 proteins regulate cell signaling and are implicated in human diseases. Dysregulated 14-3-3 levels correlate with poor cancer survival, suggesting therapeutic potential.
Area of Science:
- Molecular Biology
- Cell Signaling
- Oncology
Background:
- 14-3-3 proteins are key regulators of cellular signaling pathways.
- These proteins bind phosphoserine/phosphothreonine motifs on client proteins.
- Dysregulation of 14-3-3 proteins is linked to various human diseases, including cancer.
Purpose of the Study:
- To review the role of 14-3-3 proteins in disease pathogenesis.
- To highlight the association between 14-3-3 protein levels and cancer patient survival.
- To discuss the current landscape of 14-3-3 modulator discovery for therapeutic applications.
Main Methods:
- Literature review of studies investigating 14-3-3 proteins in physiological and pathological processes.
- Analysis of clinical data correlating 14-3-3 expression with cancer patient outcomes.
- Survey of ongoing research in the development of small molecule modulators targeting 14-3-3 proteins.
Main Results:
- 14-3-3 proteins are crucial for orchestrating signal transduction pathways.
- Abnormal 14-3-3 expression or interactions are implicated in numerous diseases.
- Elevated 14-3-3 levels are associated with poor prognosis in cancer patients.
Conclusions:
- 14-3-3 proteins represent a promising novel class of therapeutic targets.
- Targeting 14-3-3 proteins offers potential for novel cancer treatments.
- Further research into 14-3-3 modulator discovery is warranted.
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