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Solid state amorphization kinetic of alpha lactose upon mechanical milling.

Vincent Caron¹, Jean-François Willart, Ronan Lefort

¹UMET, UMR CNRS 8207, Université Lille Nord de France, F-59650 Villeneuve d'Ascq, France.

Carbohydrate Research

|October 11, 2011

Summary

Ball milling transforms alpha-lactose into an amorphous state through complex structural changes, not just a simple decrease in crystallinity. Heating this material can result in a nano-crystalline structure and is linked to degradation during melting.

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Area of Science:

Solid-state chemistry
Materials science
Crystallography

Background:

Alpha-lactose is known to undergo complete amorphization via ball milling.
Understanding the precise mechanisms of solid-state amorphization is crucial for materials processing.

Purpose of the Study:

To conduct a detailed investigation into the structural and microstructural transformations during the solid-state amorphization of alpha-lactose.
To elucidate the complex nature of the amorphization process beyond a simple crystalline-to-amorphous transition.

Main Methods:

Powder X-ray Diffraction (PXRD) for structural analysis.
Solid-state Nuclear Magnetic Resonance ((13)C CP-MAS) for detailed structural insights.
Differential Scanning Calorimetry (DSC) for thermal behavior analysis.

Main Results:

The amorphization process of alpha-lactose is structurally complex, deviating from a simple mixture of crystalline and amorphous fractions.
Heating the amorphized material can lead to the formation of a fully nano-crystalline structure.
Chemical degradation observed upon heating is closely associated with the melting process.

Conclusions:

Solid-state amorphization of alpha-lactose is a complex phenomenon requiring advanced analytical techniques for characterization.
The thermal behavior of amorphized alpha-lactose, including nanocrystallization and degradation, is intrinsically linked to its melting characteristics.