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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

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Related Experiment Video

Updated: May 28, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

[Systemic autoimmune disorders and pregnancy].

Emese Kiss1, Csaba György Kiss, Gyula Poór

  • 1Országos Reumatológiai és Fizioterápiás Intézet, Budapest. drkissemese@freemail.hu

Orvosi Hetilap
|October 11, 2011
PubMed
Summary

Managing autoimmune diseases during pregnancy has improved significantly. Careful planning and modern treatments have reduced disease flares and improved pregnancy outcomes for women with conditions like lupus and rheumatoid arthritis.

Area of Science:

  • Rheumatology
  • Immunology
  • Obstetrics

Background:

  • Systemic autoimmune diseases often affect women of reproductive age.
  • Pregnancy can influence autoimmune disease activity and pregnancy outcomes due to hormonal and immunological changes.
  • Historically, pregnancy posed significant risks for women with autoimmune conditions.

Purpose of the Study:

  • To review the current understanding of systemic autoimmune disorders in pregnancy.
  • To discuss advancements in medical management strategies for these conditions during gestation.
  • To highlight the evolving approach to childbearing in women with autoimmune diseases.

Main Methods:

  • Literature review of systemic autoimmune diseases and pregnancy.
  • Analysis of changes in disease management and outcomes over the past 30 years.

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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Related Experiment Videos

Last Updated: May 28, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

  • Examination of treatment modalities including corticosteroids, anti-thrombotic agents, methotrexate, and TNF-alpha inhibitors.

    • Main Results:

    • Significant decrease in flare rates for systemic lupus erythematosus during pregnancy.
    • Improved pregnancy outcomes in antiphospholipid syndrome with anti-thrombotic agents.
    • Enhanced remission rates in rheumatoid arthritis due to early methotrexate and TNF-alpha inhibitor use, positively impacting planned pregnancies.

    Conclusions:

    • Modern management strategies have markedly improved pregnancy outcomes for women with autoimmune diseases.
    • Maintaining low disease activity before conception is crucial for reducing pregnancy-related flares.
    • Advances in pharmacotherapy offer better control and prognosis for autoimmune conditions during pregnancy.