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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.

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Related Experiment Video

Updated: May 28, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Proteomic databases and tools to decipher post-translational modifications.

Karthik S Kamath1, Meghana S Vasavada, Sanjeeva Srivastava

  • 1Wadhwani Research Center for Biosciences and Bioengineering, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India.

Journal of Proteomics
|October 11, 2011
PubMed
Summary
This summary is machine-generated.

Post-translational modifications (PTMs) regulate protein functions and are crucial in diseases like cancer. This review highlights PTM databases and tools that aid researchers in analyzing complex proteomic data.

More Related Videos

Quantitative Analysis of Chromatin Proteomes in Disease
08:11

Quantitative Analysis of Chromatin Proteomes in Disease

Published on: December 28, 2012

Related Experiment Videos

Last Updated: May 28, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Quantitative Analysis of Chromatin Proteomes in Disease
08:11

Quantitative Analysis of Chromatin Proteomes in Disease

Published on: December 28, 2012

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Proteomics

Background:

  • Post-translational modifications (PTMs) are critical cellular regulatory mechanisms influencing protein properties and functions.
  • PTMs play significant roles in various diseases, including cancer and diabetes.
  • The dynamic nature of PTMs presents challenges for their study.

Purpose of the Study:

  • To provide a comprehensive overview of available PTM databases and software tools.
  • To analyze the critical information provided by these resources for studying PTMs.
  • To simplify the analysis of complex PTM data for the research community.

Main Methods:

  • Review of existing PTM databases and software tools.
  • Analysis of data accessibility and utility within these resources.
  • Discussion of advancements in proteomic technologies like mass spectrometry and microarrays.

Main Results:

  • Numerous databases and software tools have been developed to aid PTM research.
  • These resources offer valuable information for understanding PTMs across various organisms.
  • Advancements in high-throughput (HT) technologies facilitate PTM study.

Conclusions:

  • PTM databases and tools are essential resources for researchers.
  • Effective utilization of these tools can enhance the understanding of PTMs and their roles in biology and disease.
  • Continued development of these resources is crucial for advancing proteomic research.