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Updated: May 28, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
Published on: June 8, 2018
Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche
Sean J Markwardt1, Cristina V Dieni, Jacques I Wadiche
1Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abstract:
Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.
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