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Updated: May 28, 2026
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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
Published on: January 11, 2020
A custom-built PET phantom design for quantitative imaging of printed distributions
P J Markiewicz1, G I Angelis, F Kotasidis
1School of Cancer and Enabling Sciences, MAHSC, The University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK. p.markiewicz@manchester.ac.uk
Physics in Medicine and Biology
|October 11, 2011
Summary
This study introduces a custom PET phantom for accurate digital radioactive distributions. The novel design enhances imaging accuracy and resolution for PET scanners, overcoming practical printing challenges.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Biomedical Engineering
Background:
- Positron Emission Tomography (PET) imaging requires accurate phantoms for quantitative analysis.
- Existing PET phantom designs may have limitations in spatial resolution and quantitative accuracy.
- Digital radioactive distributions offer potential for improved phantom applications.
Purpose of the Study:
- To present a practical, custom-designed PET phantom for digital radioactive distributions.
- To achieve high quantitative accuracy and spatial resolution in PET imaging.
- To adapt methods for broad applicability across different PET scanners.
Main Methods:
- Developed a custom PET phantom capable of imaging digital radioactive distributions in transaxial and axial planes.
- Utilized a well counter (WC) for calibration, establishing the relationship between digital voxel intensities and radioactive concentrations.
- Employed computed radiography (CR) with phosphor imaging plates (IP) to assess printing uniformity and reproducibility.
Main Results:
- Demonstrated satisfactory printing uniformity and reproducibility for the custom phantom.
- Found calibration to be dependent on printing mode and cartridge state.
- Showcased good quantitative agreement between PET, CR, and WC measurements in calibration.
Conclusions:
- The custom PET phantom enables accurate digital radioactive distributions for PET imaging.
- The design is adaptable to various PET scanners, with potential for widespread use.
- Identified partial-volume effects and iterative reconstruction limits impacting HRRT brain image resolution.
