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Updated: May 28, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[A family-based association study of FXYD6 gene polymorphisms and schizophrenia]
Li-zi Jiao1, Bing Wang, Xiao-rong Niu
1Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, People's Republic of China.
Objective:
To study the association between the single nucleotide polymorphisms (SNPs) in FXYD6 gene and schizophrenia in a family-trios population.
Methods:
Six SNPs (rs10790212, rs11544201, rs555577, rs1815774, rs4938446 and rs497768) in the FXYD6 gene were genotyped by allele-specific PCR method in 101 nuclear families, and transmission disequilibrium test (TDT) was performed.
Results:
SNPs rs10790212 and rs11544201 showed significant association with schizophrenia (P<0.05). Furthermore, significant association of schizophrenia with the haplotype rs10790212-rs11544201 was found (P<0.05).
Conclusion:
FXYD6 gene might play an important role in schizophrenia susceptibility and functional analysis of FXYD6 are needed.
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