Leptomeningeal carcinomatosis from ovarian cancer

Ovarian cancer is the most common cause of mortality among women with gynecologic malignancies and the fifth leading cause of death in all women. It usually spreads locally; hematogenous dissemination is rare, most often involving the liver and lungs. Cerebral metastases are reported in less than 2% of cases and tend to localize to the parenchyma, usually in the cerebrum. Leptomeningeal involvement is exceptionally rare. We report a case of a woman with metastatic ovarian cancer who developed leptomeningeal carcinomatosis while receiving systemic chemotherapy. We also provide an extensive review of the existing literature on neoplastic meningitis from ovarian cancer.