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[Aortic elastic properties and its clinical significance in intracranial aneurysms]

Zhao-xia Pu1, Xiang-dong You, Wen-chao Weng

  • 1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|October 11, 2011
PubMed

Insights

Intracranial aneurysms (IAs) are linked to reduced aortic elasticity. Hypertension exacerbates this aortic stiffness, highlighting a significant clinical correlation for IAs patients.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Radiology

Background:

  • Intracranial aneurysms (IAs) pose significant neurological risks.
  • Aortic elastic properties are crucial for cardiovascular health.
  • Understanding the interplay between IAs and aortic mechanics is clinically relevant.

Purpose of the Study:

  • To investigate the aortic elastic properties in patients with intracranial aneurysms (IAs).
  • To determine the clinical significance of these aortic properties in the context of IAs.
  • To assess the impact of hypertension on aortic elasticity in IAs patients.

Main Methods:

  • Recruited 107 IAs patients and 108 healthy controls.
  • Measured internal aortic diameters during systole and diastole using M-mode echocardiography.
  • Calculated and compared aortic elasticity indexes, including aortic distensibility (DIS) and aortic stiffness index (SI).

Main Results:

  • IAs patients exhibited lower aortic distensibility (DIS) and higher aortic stiffness index (SI) compared to controls (P <0.001).
  • Hypertension in IAs patients (IAs-HP) was associated with significantly lower DIS and higher SI than in IAs patients without hypertension.
  • These findings remained consistent after adjusting for body surface area and body mass index.

Conclusions:

  • Abnormal aortic elasticity is a common characteristic of patients with intracranial aneurysms.
  • Hypertension is strongly correlated with the severity of aortic elasticity abnormalities in IAs patients.
  • These findings underscore the importance of assessing aortic health in IAs management.
Abstract

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