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Updated: May 28, 2026
Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
Published on: September 29, 2018
Pain relief and functional improvement remain 20 years after knee arthroplasty
John B Meding1, Lindsey K Meding, Merrill A Ritter
1The Center for Hip and Knee Surgery, St Francis Hospital Mooresville, 1199 Hadley Road, Mooresville, IN 46158, USA. jmeding@msn.com
Background:
TKA provides demonstrable pain relief and improved health-related quality of life. Yet, a decline in physical function may occur over the long term despite the absence of implant-related problems.
Questions/Purposes:
(1) Does pain relief diminish over 20 years after TKA? (2) Does function decline over 20 years in terms of Knee Society function, knee, and walking scores? And (3) what is the patient-reported activity level at most recent followup?
Patients And Methods:
We retrospectively identified 1471 patients with 1757 primary cruciate-retaining TKAs implanted between 1975 and 1989 and identified 128 living patients (8.7%) with 171 TKAs. Ninety-three patients were women. We determined Knee Society scores prospectively and UCLA scores retrospectively. Minimum followup was 20 years (average, 21.1 years; range, 20-27 years). Average age at last followup was 82.3 years (range, 45-103 years). Of the 128 patients, 66 (73 TKAs) died after 20-year followup.
Results:
Pain scores did not diminish over time (average, 49; range, 20-50). Average knee score was 78 (range, 39-97). Function, stair, and walking scores diminished over time. Average function score was 70 (range, 5-100), primarily due to an average stair score of 35 (range, 0-50); average walking score was 37 (range, 10-50). All but two patients (two TKAs) could negotiate stairs; 95 patients (124 TKAs) could walk at least five blocks; three patients (three TKAs) were housebound. Of the 62 patients still living (98 TKAs), the average UCLA activity score was 8.3 (range, 5-10).
Conclusions:
Although aging may cause a gradual decline in physical activity, an improved functional capacity and activity level continue 20 years or more after TKA.