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Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

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Updated: May 28, 2026

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins
08:24

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

Published on: November 18, 2016

Platelet cyclooxygenase expression in normal dogs.

J Thomason1, K Lunsford, K Mullins

  • 1Department of Clinical Sciences, Mississippi State University, Mississippi State, MS 39762-6100, USA. thomason@cvm.msstate.edu

Journal of Veterinary Internal Medicine
|October 12, 2011
PubMed
Summary
This summary is machine-generated.

Canine platelets express cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Aspirin increased COX-1 expression and impaired platelet function, while COX-2 expression varied significantly among dogs.

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Area of Science:

  • Veterinary Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Human platelets express cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).
  • Variations in COX-2 expression may explain differing responses to aspirin therapy.

Purpose of the Study:

  • To determine if circulating canine platelets express COX-1 and COX-2.
  • To investigate how aspirin administration affects COX expression and platelet function in dogs.

Main Methods:

  • Eight intact female hounds were studied using a repeated measures design.
  • Platelet COX-1 and COX-2 expression were measured by flow cytometry before and after 10 days of aspirin (10 mg/kg Q12h).
  • Platelet function was assessed using PFA-100(®) (collagen/epinephrine), and urine 11-dehydro-thromboxane B(2) (11-dTXB(2)) to creatinine ratio was measured.

Main Results:

  • Both COX-1 and COX-2 were detected in canine platelets.
  • Aspirin administration led to a 250% increase in COX-1 expression in all dogs.
  • COX-2 expression showed significant inter-individual variation and did not change significantly after aspirin; platelet function was impaired, and urine 11-dTXB(2) decreased in all dogs.

Conclusions:

  • Canine platelets express both COX-1 and COX-2 isoforms.
  • Aspirin increases COX-1 expression and impairs platelet function, but COX-2 expression varies considerably among dogs.
  • Inter-individual variability in platelet COX-2 expression warrants further investigation as a potential marker for variable aspirin responsiveness.