Related Experiment Video

Updated: May 28, 2026

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

Photodynamic therapy for best disease complicated by choroidal neovascularization in children

Sengul Ozdek1, Mehmet Cuneyt Ozmen, Hasan Ali Tufan

  • 1Gazi University, School of Medicine, Ophthalmology Department, Ankara, Turkey. sozdek@gazi.edu.tr

Journal of Pediatric Ophthalmology and Strabismus
|October 12, 2011
PubMed

Insights

Photodynamic therapy (PDT) effectively treated choroidal neovascularization (CNV) in children with Best vitelliform macular dystrophy (BVMD). Visual acuity improved or stabilized in most patients during a 25-month follow-up.

Area of Science:

  • Ophthalmology
  • Medical therapy

Background:

  • Best vitelliform macular dystrophy (BVMD) can lead to choroidal neovascularization (CNV).
  • Pediatric CNV management requires effective treatment options.

Observation:

  • Five eyes of four children with BVMD and CNV underwent a single photodynamic therapy (PDT) session.
  • Treatment response was assessed using fluorescein angiography and optical coherence tomography.

Findings:

  • All treated eyes showed positive responses to PDT.
  • Four out of five eyes experienced significant visual acuity improvements.
  • Visual acuity gains were maintained for a mean follow-up of 25 months.

Implications:

  • PDT with verteporfin presents a promising therapeutic strategy for pediatric CNV secondary to BVMD.
  • Further research may validate PDT as a standard treatment for this condition.
Abstract

More Related Videos

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal07:24

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

Published on: September 12, 2025

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...