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Related Experiment Video

Updated: May 28, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

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Published on: February 28, 2012

Apixaban: first global approval.

Julia Watson¹, Glen Whiteside, Caroline Perry

¹RD Insight, Wolters Kluwer Pharma Solutions, Auckland, New Zealand.

|October 12, 2011

Summary

Apixaban, a direct factor Xa inhibitor, is now approved in the EU for preventing venous thromboembolism (VTE) after hip or knee surgery. Further development continues for other thrombotic conditions.

Area of Science:

Pharmacology
Cardiovascular Medicine
Drug Development

Background:

Apixaban is an oral direct factor Xa inhibitor.
It is being developed for thrombotic disorders by Bristol-Myers Squibb and Pfizer.
Previous development for acute coronary syndromes was halted.

Purpose of the Study:

To summarize the development milestones of apixaban.
To highlight the first approval for venous thromboembolism (VTE) prevention post-hip or knee replacement.

Main Methods:

Review of apixaban's development pathway.
Summary of regulatory submissions and trial outcomes.

Main Results:

Apixaban received EU approval for VTE prevention after hip or knee replacement.

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

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A rolling submission for stroke prevention in atrial fibrillation is underway in the US.

Phase III trials are ongoing for VTE and atrial fibrillation indications.

Conclusions:

Apixaban's development has led to its first major regulatory approval.
The drug shows promise for various thrombotic conditions, with ongoing global development.