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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

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Published on: May 25, 2020

Auditory processing deficits in individuals with primary open-angle glaucoma.

Gary Rance1, Fleur O'Hare, Stephen O'Leary

  • 1Department of Otolaryngology, University of Melbourne, Victoria, Australia. grance@unimelb.edu.au

International Journal of Audiology
|October 12, 2011
PubMed
Summary
This summary is machine-generated.

A significant portion of individuals with primary open-angle glaucoma experience auditory dysfunction, including abnormal auditory brainstem responses and impaired perception. This suggests a broader neuronal impact beyond the visual system in glaucoma patients.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Audiology

Background:

  • Sensory pathways, particularly auditory and visual systems, are susceptible to mitochondrial dysfunction.
  • Primary open-angle glaucoma (POAG) is a neurodegenerative optic nerve disease linked to mitochondrial abnormalities.
  • Emerging evidence suggests POAG may affect other neuronal systems.

Purpose of the Study:

  • To investigate auditory processing in individuals diagnosed with POAG.
  • To determine if POAG is associated with auditory system dysfunction.
  • To explore the systemic impact of POAG on neuronal function.

Main Methods:

  • Twenty-seven POAG subjects and matched controls underwent auditory assessments.
  • Electrophysiologic tests included auditory brainstem response (ABR).
  • Auditory temporal processing and speech perception in quiet and noise were evaluated.

Main Results:

  • While most POAG subjects had normal hearing, 22% (6/27) exhibited abnormal ABRs.
  • Impaired auditory perception was noted in one or both ears in affected individuals.
  • These auditory deficits occurred alongside the diagnosis of POAG.

Conclusions:

  • A notable percentage of POAG patients show auditory dysfunction, indicating systemic neuronal susceptibility.
  • Glaucoma may impact auditory pathways, suggesting a broader neurodegenerative process.
  • Individuals with POAG may face communication challenges in daily listening environments.