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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Overview of Cell Signaling01:23

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Optical Control of Living Cells Electrical Activity by Conjugated Polymers
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Published on: January 28, 2016

Electrically controlled molecular recognition harnessed to activate a cellular response.

Arbel Artzy-Schnirman1, Dan Blat, Yael Talmon

  • 1Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel.

Nano Letters
|October 12, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel electrical-to-biological transducer. This system uses a two-state electronic antigen and engineered T-cells to translate electrical signals into cellular responses, enabling new bioelectronic interfaces.

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Photostimulation by Femtosecond Laser Activates Extracellular-signal-regulated Kinase (ERK) Signaling or Mitochondrial Events in Target Cells
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Published on: July 6, 2019

Area of Science:

  • Bioelectronics
  • Synthetic Biology
  • Cellular Engineering

Background:

  • Integrating electronic devices with biological systems offers enhanced computing and memory capabilities.
  • Effective communication between electronics and cells requires reliable signal transduction from electrical to biochemical cues.
  • Molecular recognition principles, common in biological pathways, provide a model for designing such interfaces.

Purpose of the Study:

  • To develop a generic and efficient electrical-to-biological transducer.
  • To demonstrate a system capable of converting electrical signals into specific cellular responses.
  • To create a controllable bioelectronic interface using engineered cells.

Main Methods:

  • Designed a two-state electronic antigen that can switch between 'on' and 'off' states.
  • Engineered chimeric T-cell receptors to selectively bind the electronic antigen only in its 'on' state.
  • Utilized electrical signals to control the antigen's state and subsequent T-cell activation.

Main Results:

  • T-cells expressing the engineered receptors remained inactive when the antigen was in the 'off' state.
  • Switching the electronic antigen to the 'on' state via an electrical signal successfully triggered T-cell recognition and activation.
  • Demonstrated a functional electrical-to-biological signal transduction pathway.

Conclusions:

  • The developed transducer provides a novel method for interfacing electronic signals with biological systems.
  • This technology enables precise control over cellular behavior using external electrical stimuli.
  • The findings pave the way for advanced applications in bioelectronic medicine and synthetic biology.