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Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: May 28, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Induced pluripotent stem cells: progress towards a biomedical application.

Lucio Barile¹, Claudia Altomare, Antonio Zaza

¹Dipartimento di Biotecnologie e Bioscienze, Università degli Studi Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.

Expert Review of Cardiovascular Therapy

|October 12, 2011

Summary

Induced pluripotent stem cells (iPSCs) offer regenerative medicine potential but face reprogramming challenges. A new method efficiently generates precursor-derived cardiomyocytes from various human cells, advancing disease modeling and therapy.

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

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Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

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Published on: December 21, 2016

Area of Science:

Stem cell biology
Regenerative medicine

Background:

Induced pluripotent stem cells (iPSCs) were first generated by Takahashi and Yamanaka 5 years ago, offering potential alternatives to embryonic stem cells (ESCs) for autologous transplantation.
Clinical application of iPSCs is limited by risks of aberrant reprogramming and transgene-related complications.

Discussion:

Patient-derived iPSCs are valuable for in vitro disease modeling, allowing analysis of human genetic syndromes and drug modulation.
iPSC-derived cardiomyocytes can recapitulate disease phenotypes at the cellular level, validated in genetic syndrome models.

Key Insights:

A novel process efficiently prepares precursor-derived cardiomyocytes from various human precursors, including ESCs and iPSCs.
This method demonstrates unprecedented efficiency and applicability across multiple somatic cell types.

Outlook:

The development of reliable and reproducible methods for iPSC reprogramming, expansion, and differentiation is crucial for advancing stem cell technologies.
The described process may significantly advance precursor-derived technologies if proven reproducible across different laboratories.