Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Limits with Oscillating Discontinuities

Limits with Oscillating Discontinuities

An oscillating discontinuity is a type of discontinuity in which a function’s values fluctuate infinitely often as the input approaches a particular point. Unlike jump discontinuities, where the function suddenly shifts between two values, or infinite discontinuities, where the function diverges without bound, an oscillating discontinuity arises from rapid back-and-forth variation. Because the function never stabilizes toward a single value, no finite limit exists at that point.One of the most...

Design Example: Maintaining Level of an Embankment

Design Example: Maintaining Level of an Embankment

Constructing a roadway embankment over uneven terrain requires precise leveling to ensure stability and proper drainage. Surveyors use a leveling instrument and staff to calculate ground elevations and determine the required fill material at each point along the embankment alignment.The process begins by positioning a leveling instrument near a benchmark with a known elevation. A backsight reading establishes the instrument height, which serves as a reference for subsequent measurements. A...

Robbers Cave

Robbers Cave

During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension could be...

Quarrying of Stone

Quarrying of Stone

Quarrying is the process of extracting stone from a quarry, where specialized techniques are employed to remove large blocks of stone safely and efficiently. This process can involve controlled explosions or more precision-oriented methods such as cutting and drilling.
One common method involves using a diamond belt saw to cut large blocks from the quarry face. These blocks can be about 50 feet long and 12 feet high. After the initial vertical cut, drilling is performed at the base of the block.

Areas Within Irregular Boundaries

Areas Within Irregular Boundaries

Calculating areas within irregular boundaries, such as along rivers or curved roads, is crucial in various fields, including surveying, engineering, and environmental management. Surveyors often begin by creating a traverse, a connected series of straight lines approximating the area's boundary. The coordinates of each traverse point are essential for calculating the enclosed area. The double meridian distance formula is a widely used technique for this purpose. This method utilizes the...

Anchoring Junctions

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prediction of activity cliffs on the basis of images using convolutional neural networks.

Journal of computer-aided molecular design·2021

Same author

Evolution of assay interference concepts in drug discovery.

Expert opinion on drug discovery·2021

Same author

Adapting the DeepSARM approach for dual-target ligand design.

Journal of computer-aided molecular design·2021

Same author

Data set of competitive and allosteric protein kinase inhibitors confirmed by X-ray crystallography.

Data in brief·2021

Same author

Evaluation of multi-target deep neural network models for compound potency prediction under increasingly challenging test conditions.

Journal of computer-aided molecular design·2021

Same author

Predicting Isoform-Selective Carbonic Anhydrase Inhibitors via Machine Learning and Rationalizing Structural Features Important for Selectivity.

ACS omega·2021

Search research articles

Related Experiment Video

Updated: May 28, 2026

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Published on: August 5, 2016

Exploring SAR continuity in the vicinity of activity cliffs.

Vigneshwaran Namasivayam¹, Preeti Iyer, Jürgen Bajorath

¹Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität Bonn, Dahlmannstrasse 2, Germany.

Chemical Biology & Drug Design

|October 12, 2011

Summary

Activity cliffs, where similar compounds have vastly different potencies, can unexpectedly contain regions of continuous structure-activity relationships. This study used particle swarm optimization to find these rare, continuous areas near activity cliffs.

More Related Videos

Data Processing Methods for 3D Seismic Imaging of Subsurface Volcanoes: Applications to the Tarim Flood Basalt

Data Processing Methods for 3D Seismic Imaging of Subsurface Volcanoes: Applications to the Tarim Flood Basalt

Published on: August 7, 2017

Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope

Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope

Published on: May 28, 2016

Related Experiment Videos

Last Updated: May 28, 2026

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Published on: August 5, 2016

Data Processing Methods for 3D Seismic Imaging of Subsurface Volcanoes: Applications to the Tarim Flood Basalt

Data Processing Methods for 3D Seismic Imaging of Subsurface Volcanoes: Applications to the Tarim Flood Basalt

Published on: August 7, 2017

Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope

Comprehensive Characterization of Extended Defects in Semiconductor Materials by a Scanning Electron Microscope

Published on: May 28, 2016

Area of Science:

Medicinal Chemistry
Computational Chemistry
Drug Discovery

Background:

Activity cliffs represent extreme discontinuity in structure-activity relationships (SARs).
SAR data is often heterogeneous, containing both continuous and discontinuous components.
Continuity and discontinuity are typically found in separate compound series.

Purpose of the Study:

To investigate the presence of SAR continuity in the vicinity of activity cliffs.
To develop a computational method for identifying SAR continuity near cliffs.

Main Methods:

Designed a computational approach using particle swarm optimization.
Examined the structural neighborhood of activity cliffs for continuous SAR components.

Main Results:

SAR continuity near activity cliffs was rarely observed.
Notable SAR continuity was detected in the structural neighborhood of some prominent activity cliffs.
Analysis revealed that SAR environments of activity cliffs are not exclusively discontinuous.

Conclusions:

Activity cliffs can exhibit local SAR continuity alongside discontinuity.
SAR continuity and discontinuity can coexist in a concerted manner within structurally related compound series.