Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liposomes designed to avoid the reticuloendothelial system.

D Papahadjopoulos1, A Gabizon

  • 1Cancer Research Institute, University of California, San Francisco 94143.

Progress in Clinical and Biological Research
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatic arterial bolus chemotherapy for colorectal metastases using an implantable port.

International journal of oncology·2011
Same author

Folate-mediated tumor cell uptake of quantum dots entrapped in lipid nanoparticles.

Journal of controlled release : official journal of the Controlled Release Society·2007
Same author

Comparing therapeutic and prophylactic protection against the lethal effect of paraoxon.

Toxicological sciences : an official journal of the Society of Toxicology·2003
Same author

Tumor targeting using anti-her2 immunoliposomes.

Journal of controlled release : official journal of the Controlled Release Society·2001
Same author

Expression of DeltaF508 CFTR in normal mouse lung after site-specific modification of CFTR sequences by SFHR.

Gene therapy·2001
Same author

Skin toxic effects of polyethylene glycol-coated liposomal doxorubicin.

Archives of dermatology·2000
Same journal

DNA homology and chromosome stability: a sensitive yeast genetic system for identifying double-stranded DNA damage.

Progress in clinical and biological research·2018
Same journal

Endotoxin and sepsis: molecular mechanisms of pathogenesis, host resistance, and therapy. Proceedings of the 4th Conference of the International Endotoxin Society. Nagoya, Japan, October 23-27, 1996.

Progress in clinical and biological research·1998
Same journal

The pathogenic role of LBP in gram-negative sepsis and septic shock.

Progress in clinical and biological research·1998
Same journal

The role of interleukin 6 in endotoxin-induced inflammatory responses.

Progress in clinical and biological research·1998
Same journal

Role of nitric oxide and reactive oxygen species in endotoxin shock.

Progress in clinical and biological research·1998
Same journal

Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells.

Progress in clinical and biological research·1998
See all related articles

Adding specific glycolipids to liposomes significantly extends their presence in the bloodstream and enhances tumor accumulation. This advance offers new possibilities for targeted cancer diagnostics and therapies.

Area of Science:

  • Lipid-based drug delivery systems
  • Nanomedicine
  • Pharmacokinetics

Background:

  • Liposomes are widely investigated for drug delivery.
  • Their rapid clearance by the reticuloendothelial system (RES) limits therapeutic efficacy.
  • Modifying liposome composition is crucial for improving in vivo performance.

Purpose of the Study:

  • To investigate the impact of glycolipid inclusion on liposome circulation time and biodistribution.
  • To explore the potential of modified liposomes for enhanced tumor targeting.
  • To assess the implications for in vivo diagnostics and therapeutics.

Main Methods:

  • Formulation of liposomes using phosphatidylcholine or sphingomyelin with cholesterol.
  • Incorporation of specific glycolipids into the liposome bilayers.

Related Experiment Videos

  • Evaluation of liposome circulation half-life in vivo.
  • Assessment of liposome uptake by liver and spleen.
  • Quantification of liposome accumulation in implanted tumors.

    • Main Results:

    • Inclusion of certain glycolipids drastically prolonged liposome circulation time.
    • RES uptake by liver and spleen was significantly reduced.
    • Substantial increase in liposome accumulation within implanted tumors was observed.

    Conclusions:

    • Controlling liposome circulation time via glycolipid modification is achievable.
    • Reduced RES uptake facilitates enhanced tumor targeting.
    • These findings open new avenues for liposome-based cancer diagnostics and therapeutics.