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Association between γ-glutamyltransferase, adiponectin and arterial stiffness
Jong Suk Park1, Sin Ae Kang, Jeong Seon Yoo
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Journal of Atherosclerosis and Thrombosis
|October 12, 2011
Summary
Serum gamma-glutamyltransferase (GGT) is linked to arterial stiffness. This study found GGT independently associated with increased peripheral pulse wave velocity, suggesting a role in cardiovascular health.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Metabolic Syndrome
Background:
- Serum gamma-glutamyltransferase (GGT) is a marker for hepatic dysfunction.
- Emerging evidence links GGT to cardiovascular mortality and atherosclerosis.
- Adiponectin's role in atherosclerosis is significant but not fully understood.
Purpose of the Study:
- To investigate the relationship between serum GGT, adiponectin, and arterial stiffness.
- To determine if GGT or adiponectin are associated with arterial stiffness.
Main Methods:
- 2846 subjects from Seoul, Korea, were analyzed.
- Metabolic syndrome parameters, plasma adiponectin, and pulse wave velocity (PWV) were measured.
- GGT levels were assessed alongside anthropometric and biochemical profiles.
Main Results:
- Pulse wave velocity (PWV) increased and adiponectin decreased across GGT tertiles.
- Peripheral PWV correlated with age, blood pressure, BMI, and GGT.
- GGT was a significant independent predictor of increased peripheral PWV.
Conclusions:
- Serum GGT is independently associated with increased arterial stiffness.
- No correlation was found between adiponectin and arterial stiffness in this cohort.
