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Human maxillary sinuses augmented with mineralized, solvent-dehydrated bone allograft: a longitudinal case series
Susanna Annibali1, Maria Paola Cristalli, Gerardo La Monaca
1Department of Odontostomatological and Maxillofacial Sciences, Oral Surgery Unit, Sapienza University of Rome, Rome, Italy. susanna.annibali@uniroma1.it
Implant Dentistry
|October 12, 2011
Summary
Mineralized, solvent-dehydrated bone allograft (MSDBA) successfully regenerated maxillary sinus floors. Dental implants placed in the regenerated bone demonstrated long-term clinical and radiographic stability over 5 years.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Dental Implantology
Background:
- Maxillary sinus floor augmentation is crucial for dental implant placement.
- Assessing the long-term stability of regenerated bone is essential.
Purpose of the Study:
- To evaluate the clinical stability of maxillary sinus floors regenerated with mineralized, solvent-dehydrated bone allograft (MSDBA).
- To assess the osseointegration and stability of dental implants placed in MSDBA-grafted sites after at least 5 years of function.
Main Methods:
- Prospective case series involving 11 sinus augmentations in 7 patients.
- Graft material: 50% cortical and 50% cancellous MSDBA.
- Histology, histomorphometry, and immunohistochemistry of bone specimens; radiographic evaluation post-loading and annually.
Main Results:
- No complications or failures reported.
- Histology showed bone formation around MSDBA particles; histomorphometry revealed 39% newly formed bone.
- After a mean 5.1-year follow-up, implants and regenerated bone were clinically stable with no significant ridge volume loss.
Conclusions:
- Composite MSDBA allografts effectively form quality maxillary sinus bone.
- Regenerated bone and implants demonstrated excellent clinical and radiographic stability over 5 years post-function.
