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Updated: May 28, 2026

A Polyaniline-based Sensor of Nucleic Acids

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Pt nanoflower/polyaniline composite nanofibers based urea biosensor.

Wenzhao Jia¹, Liang Su, Yu Lei

¹Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA.

Biosensors & Bioelectronics

|October 12, 2011

Summary

Researchers developed novel hybrid nanofibers combining polyaniline (PANi) and platinum (Pt) nanoflowers for sensitive urea detection. This advanced material offers a wide linear range and excellent anti-interference properties, paving the way for new biosensing applications.

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Area of Science:

Materials Science
Nanotechnology
Electrochemistry

Background:

Hybrid materials offer enhanced properties over pure components.
Conducting polymers like polyaniline (PANi) are versatile for functional applications.
Nanostructured materials, such as platinum (Pt) nanoflowers, can improve catalytic and sensing performance.

Purpose of the Study:

To synthesize and characterize novel hybrid polyaniline (PANi) nanofibers integrated with platinum (Pt) nanoflowers.
To develop a sensitive and selective sensing platform for urea detection using the fabricated Pt/PANi hybrid nanofibers.
To investigate the sensing mechanism and performance of the hybrid material in a flow-injection-analysis (FIA) system.

Main Methods:

In situ polymerization of aniline on electrospun nanofibers to form PANi nanofibers.

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Electrodeposition of Pt nanoflowers onto PANi nanofibers using cyclic voltammetry (CV).

Immobilization of urease enzyme onto the Pt/PANi hybrid nanofibers for urea sensing.

Main Results:

Successfully synthesized Pt/PANi hybrid nanofibers with controllable Pt nanoflower coverage.
Demonstrated a sensitive urea detection platform with a wide linear range (up to 20 mM) and a low limit of detection (10 μM).
Exhibited excellent anti-interference properties against chloride ions and elucidated a dual sensing mechanism involving PANi conductivity changes and Pt nanoflower interactions.

Conclusions:

The developed Pt/PANi hybrid nanofibers represent a promising advanced material for electrochemical sensing applications.
The facile synthesis strategy and excellent sensing performance highlight the potential for creating diverse composite nanofibers for various applications.
The dual sensing mechanism provides valuable insights for designing next-generation biosensors.