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Related Experiment Video

Updated: May 28, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Virus manipulation of cell cycle.

R Nascimento¹, H Costa, R M E Parkhouse

¹Instituto Gulbenkian de Ciencia, Oeiras, Portugal. rutenasc@igc.gulbenkian.pt

|October 12, 2011

Summary

Viruses manipulate the host cell cycle for replication. Understanding these viral strategies offers new avenues for developing effective antiviral therapies and vaccines.

Area of Science:

Virology
Cell Biology
Immunology

Background:

Viruses rely on host cell machinery for replication, often exploiting specific cell cycle phases.
Viruses employ sophisticated strategies to manipulate the host cell cycle, inducing favorable conditions for viral proliferation.

Purpose of the Study:

To explore viral strategies for manipulating the host cell cycle.
To investigate how understanding viral evasion mechanisms can inform the development of novel antiviral therapies.

Main Methods:

Analysis of viral interactions with cyclin and cyclin-dependent kinase complexes.
Examination of viral subversion of intracellular signaling pathways controlling cell division.

Main Results:

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Viruses associate with cell cycle regulators to subvert host functions.

Targeting key viral manipulation strategies can lead to effective therapeutic interventions.

Conclusions:

Viral manipulation of the cell cycle presents a promising target for antiviral drug and vaccine development.
Studying viral evasion tactics reveals fundamental host cell control mechanisms and signaling pathways.