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The effect of paracetamol on postoperative nausea and vomiting during the first 24 h after strabismus surgery: a

Oya Y Cok1, H Evren Eker, Aysel Pelit

  • 1Department of Anaesthesiology and Reanimation, Baskent University, Ankara, Turkey. oyacok@yahoo.com

European Journal of Anaesthesiology
|October 12, 2011
PubMed

Insights

Intravenous paracetamol significantly reduced postoperative nausea and vomiting (PONV) in children undergoing strabismus surgery. This finding highlights paracetamol as an effective option for managing PONV in pediatric ophthalmic procedures.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery
  • Pharmacology

Background:

  • Strabismus surgery is a common pediatric ophthalmic procedure.
  • Postoperative nausea and vomiting (PONV) is a frequent complication in children following strabismus surgery.

Purpose of the Study:

  • To evaluate the efficacy of intravenous paracetamol in mitigating PONV in pediatric patients undergoing strabismus surgery.

Main Methods:

  • A prospective, randomized, double-blind, placebo-controlled study was conducted at a university hospital.
  • Ninety children (ages 2-14) received intravenous dexamethasone, followed by either saline (control) or paracetamol (15 mg/kg).
  • The primary outcome was the incidence of PONV within the first 24 hours postoperatively.

Main Results:

  • The incidence of nausea was significantly lower in the paracetamol group (14.6%) compared to the saline group (33%) (P=0.038).
  • Vomiting also occurred significantly less frequently in the paracetamol group (7.3%) versus the saline group (24.4%) (P=0.030).
  • Fewer analgesic administrations were required in the paracetamol group during the first 24 hours post-surgery (P=0.001).

Conclusions:

  • Intraoperative administration of intravenous paracetamol effectively reduces the incidence of PONV in children after strabismus surgery within the first 24 hours.
Abstract

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