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Case for diagnosis.

Cristina Paula Salaro¹, Georgi Tchernev

¹University of Brasilia, DF, Brazil. dermatologic@hotmail.com

Anais Brasileiros De Dermatologia

|October 12, 2011

Summary

A fifty-five-year-old male was diagnosed with cutaneous diffuse B cell lymphoma presenting as leg lesions. Chemotherapy led to partial remission of this rare B cell malignancy.

Area of Science:

Dermatology
Oncology
Hematology

Background:

Cutaneous lymphomas are rare malignancies affecting the skin.
Diffuse B cell lymphoma (DBCL) can manifest in the skin, often presenting as plaques or nodules.
Multisystem involvement, including cardiac, renal, and endocrine conditions, can occur in advanced lymphoma cases.

Observation:

A 55-year-old male presented with a 6-month history of infiltrated plaques and nodules on his left leg.
The patient had a history of cardiopathy, nephropathy, and endocrinopathy.
Skin biopsy revealed histopathological and immunohistochemical evidence of cutaneous diffuse B cell lymphoma.

Findings:

Immunohistochemistry confirmed the diagnosis with positive markers for CD 20, CD 79a, and Ki-67.

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The lymphoma cells expressed B cell markers, consistent with diffuse B cell lymphoma.

Ki-67 proliferation index indicated a moderate to high proliferation rate.

Implications:

Early diagnosis and appropriate treatment are crucial for managing cutaneous diffuse B cell lymphoma.
Chemotherapy regimens, such as cyclophosphamide, adriamycin, and vincristine (CHOP), can induce remission.
Further research into targeted therapies and long-term outcomes for cutaneous B cell lymphomas is warranted.