Related Experiment Video

Updated: May 28, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Intercellular adhesion molecule-1 E469K gene polymorphism and coronary artery disease in the Chinese population: a

Li Yanyan1

  • 1Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, China. lyynjmu123@126.com

Clinical Cardiology
|October 12, 2011
PubMed

Insights

The intercellular adhesion molecule-1 (ICAM-1) E469K gene polymorphism is linked to coronary artery disease (CAD) risk in the Chinese population. This meta-analysis suggests the K allele may increase susceptibility to CAD.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Population Studies

Background:

  • The intercellular adhesion molecule-1 (ICAM-1) E469K gene polymorphism has been investigated for its association with coronary artery disease (CAD) susceptibility.
  • Previous studies have yielded controversial results regarding this link.

Purpose of the Study:

  • To investigate the association between the ICAM-1 E469K gene polymorphism and CAD risk.
  • To explore the relationship in the Chinese population through a meta-analysis.

Main Methods:

  • A meta-analysis was conducted on 11 studies, including a total of 3065 subjects.
  • The random effect model was used to assess the pooled odds ratio (OR) for the K allele frequency of the ICAM-1 E469K gene.

Main Results:

  • The K allele frequency was 0.67 in the CAD group and 0.60 in the control group.
  • A significant association was found between the ICAM-1 E469K gene polymorphism and CAD in the Chinese population (pooled OR = 1.32, 95% CI: 1.02-1.72, P = 0.04).
  • High heterogeneity was observed (P(heterogeneity) < 0.00001; I(2) = 81.8%).

Conclusions:

  • The K allele frequency of the ICAM-1 E469K gene is associated with CAD risk in the Chinese population.
  • The K allele may contribute to increased susceptibility to coronary artery disease.
Abstract

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...