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Decreased lung carcinoma cell functions on select polymer nanometer surface features.

Lijuan Zhang¹, Thomas J Webster

¹Department of Chemistry, School of Engineering, Brown University, Providence, Rhode Island 02912, USA.

Journal of Biomedical Materials Research. Part A

|October 12, 2011

Summary

Biomaterial nanotopography influences lung cancer cell behavior. Poly-lactic-co-glycolic (PLGA) films with specific nanoscale features modulated cell adhesion, proliferation, and vascular endothelial growth factor (VEGF) synthesis, offering insights for regenerative medicine.

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Area of Science:

Biomaterials Science
Cancer Biology
Regenerative Medicine

Background:

Biomaterial nanotopographies can significantly influence various cell functions.
Understanding these interactions is crucial for developing advanced biomaterials.

Purpose of the Study:

To investigate the effect of poly-lactic-co-glycolic (PLGA) nanotopographies on lung epithelial carcinoma cell functions.
To analyze cell adhesion, proliferation, apoptosis, and vascular endothelial growth factor (VEGF) synthesis on PLGA films with defined surface features.

Main Methods:

Fabrication of PLGA films with nano-smooth, 23 nm, 300 nm, and 400 nm hemispherical nanotopographies using cast-molding and solvent evaporation.
Characterization of surface chemistry and topography using atomic force microscopy, electron spectroscopy for chemical analysis, and water contact angle measurements.

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Systematic evaluation of lung epithelial carcinoma cell adhesion, proliferation, apoptosis, and VEGF synthesis on the fabricated PLGA films.

Main Results:

Reduced lung epithelial carcinoma cell adhesion and proliferation were observed on nano-smooth and 400 nm PLGA surfaces.
Significantly decreased VEGF synthesis was noted on the 23 nm nanotopography compared to nano-smooth PLGA films.
Cell morphology varied across different nanotopographies, indicating topographical influence on cell behavior.

Conclusions:

PLGA nanotopography plays a critical role in modulating lung carcinoma cell functions, including adhesion, proliferation, and VEGF secretion.
These findings provide foundational insights for designing PLGA-based biomaterials for applications in regenerative medicine and cancer therapy.
Tailoring nanotopography offers a potential strategy to control cancer cell behavior on biomaterials.