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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

[Eosinophilic esophagitis: update 2011].

Sébastien Godat1, Darius Moradpour, Alain Schoepfer

  • 1Service de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne. Sebastien.Godat@chuv.ch

Revue Medicale Suisse
|October 13, 2011
PubMed
Summary
This summary is machine-generated.

Eosinophilic esophagitis (EoE), a growing cause of dysphagia, is effectively treated with topical corticosteroids or diet changes. While dilation eases symptoms, it doesn't address underlying inflammation, leaving long-term strategies undefined.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Context:

  • Eosinophilic esophagitis (EoE) is increasingly prevalent globally, particularly in Western countries.
  • It is a primary cause of dysphagia in adults and is more common in males, often linked to allergies.

Purpose:

  • To review the current understanding and management of eosinophilic esophagitis (EoE).
  • To highlight diagnostic criteria and therapeutic options for EoE.

Summary:

  • Diagnosis involves esophageal symptoms, eosinophilic infiltration, and exclusion of other causes.
  • Topical corticosteroids rapidly improve active EoE clinically and histologically.
  • Elimination diets show comparable efficacy to corticosteroids, especially in children.
  • Esophageal dilation alleviates stricture symptoms but not inflammation.

Impact:

  • Current treatments offer symptomatic relief and histological improvement for active EoE.
  • Dietary interventions are effective, particularly for pediatric EoE.
  • The need for defined long-term therapeutic strategies for EoE remains critical.