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Respiratory Syncytial Virus Disease

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Updated: May 28, 2026

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

Published on: January 26, 2019

Respiratory syncytial virus vaccine development.

Julia L Hurwitz¹

¹Department of Infectious Diseases, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. julia.hurwitz@stjude.org

Expert Review of Vaccines

|October 13, 2011

Summary

Respiratory syncytial virus (RSV) causes severe respiratory illness in young children, with no current vaccine available. Research is exploring immune strategies to develop an effective RSV vaccine.

Area of Science:

Virology
Immunology
Vaccinology

Background:

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and young children globally.
Currently, only supportive care is recommended for RSV infections, which contribute to an estimated 160,000 deaths annually.
Despite extensive research over 50 years, a licensed RSV vaccine remains unavailable.

Purpose of the Study:

To review past and present research efforts focused on developing an RSV vaccine.
To explore strategies for harnessing innate and adaptive immunity against RSV.
To identify key considerations for future RSV vaccine development.

Main Methods:

Comprehensive review of historical and ongoing research in RSV vaccine development.

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Analysis of various candidate vaccine products and immunization strategies.

Examination of immunological and virological approaches to combat RSV.

Main Results:

A wide range of candidate RSV vaccines and strategies have been investigated.
Efforts have focused on leveraging both innate and adaptive immune responses.
No vaccine has yet achieved licensure, highlighting the challenges in RSV vaccine development.

Conclusions:

Developing a successful RSV vaccine requires learning from past experiences.
Integrated research efforts combining immunology and virology are crucial.
Future vaccine development may benefit from a multidisciplinary approach.