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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 28, 2026

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis
08:48

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Published on: July 11, 2025

Prospective on Mycobacterium tuberculosis proteomics.

M Carolina Mehaffy1, Nicole A Kruh-Garcia, Karen M Dobos

  • 1Department of Microbiology, Immunology and Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, Colorado 80523, United States.

Journal of Proteome Research
|October 13, 2011
PubMed
Summary
This summary is machine-generated.

Mycobacterium tuberculosis (Mtb) research is advancing with functional proteomics. New mass spectrometry methods offer novel insights into Mtb protein functions and networks for tuberculosis discovery.

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Related Experiment Videos

Last Updated: May 28, 2026

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis
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Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Published on: July 11, 2025

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis
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Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis

Published on: September 26, 2025

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis

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Area of Science:

  • Microbiology
  • Proteomics
  • Biochemistry

Background:

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major global health challenge.
  • Significant progress has been made in understanding Mtb's physiology, virulence, and pathogenesis.
  • However, the functions of approximately 25% of the Mtb genome and most of its proteins remain uncharacterized.

Purpose of the Study:

  • To review the application of functional proteomics, particularly protein mass spectrometry, in Mtb research.
  • To explore novel perspectives and targeted mass spectrometry methods in TB research.
  • To highlight the potential of proteomics for advancing TB discovery and understanding Mtb.

Main Methods:

  • Protein mass spectrometry
  • Functional proteomics approaches
  • Targeted mass spectrometry techniques

Main Results:

  • Protein mass spectrometry provides new insights into Mtb biology.
  • Functional proteomics is crucial for understanding Mtb protein networks.
  • Targeted mass spectrometry shows promise for TB research and drug discovery.

Conclusions:

  • Functional proteomics is revolutionizing the study of Mycobacterium tuberculosis.
  • Advanced mass spectrometry techniques offer powerful tools for TB research.
  • Further exploration of Mtb proteomics will accelerate TB discovery and control efforts.