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Caspases

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.

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Related Experiment Video

Updated: May 28, 2026

Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction

Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction

Published on: January 12, 2016

Inner ear dysfunction in caspase-3 deficient mice.

Tomoko Makishima¹, Lara Hochman, Patrick Armstrong

¹Department of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA. tomakish@utmb.edu

BMC Neuroscience

|October 13, 2011

Summary

This summary is machine-generated.

Caspase-3 deficiency in mice leads to hearing loss and vestibular dysfunction, impacting balance and inner ear development. This highlights caspase-3

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Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

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Published on: February 21, 2016

Area of Science:

Neuroscience
Otolaryngology
Developmental Biology

Background:

Caspase-3 is a key enzyme in apoptosis, crucial for cell death pathways.
Caspase-3 deficiency in mice causes cochlear hair cell and spiral ganglion cell loss, linked to hearing impairment.
The vestibular phenotype in caspase-3 deficient mice remains largely uncharacterized.

Purpose of the Study:

To investigate the vestibular phenotype and inner ear anatomy in caspase-3 deficient (Casp3(-/-)) mice.
To determine the role of caspase-3 in the development and function of the auditory and vestibular systems.

Main Methods:

Auditory Brainstem Response (ABR) and Distortion Product Otoacoustic Emission (DPOAE) testing were performed.
Vestibulo-ocular reflex (VOR) testing, specifically lateral canal VOR, was conducted.
Inner ear anatomy and histology were analyzed, focusing on vestibular organs and hair cell counts.

Main Results:

Casp3(-/-) mice exhibited significantly elevated ABR thresholds and decreased DPOAE responses, indicating hearing loss.
Casp3(-/-) mice showed hyperactivity, circling behavior, and minimal lateral canal VOR response, suggesting vestibular dysfunction.
Histological analysis revealed vestibular organ hypomorphism, particularly in the anterior semicircular canal, with reduced hair cell numbers in Casp3(-/-) mice.

Conclusions:

Caspase-3 is essential for normal cochlear function and hearing.
Caspase-3 plays a critical role in the normal development and function of the vestibular system.
The study elucidates the comprehensive impact of caspase-3 deficiency on inner ear structures and functions.