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Updated: May 28, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
[Peripheral intravenous catheter-related phlebitis]
Simone van der Sar-van der Brugge1, E F M Ward Posthuma
1Reinier de Graaf Gasthuis, afd. Interne Geneeskunde, Delft, the Netherlands. svandersar@gmail.com
Phlebitis, a common intravenous catheter complication, can be septic or chemical. Current evidence suggests replacing catheters only when clinically indicated, not routinely.
Area of Science:
- Medical Complications
- Infectious Diseases
- Vascular Access
Background:
- Phlebitis is a frequent complication associated with intravenous (IV) catheter use.
- Thrombophlebitis, a specific type of phlebitis involving a blood clot, can arise from IV catheterization.
- Understanding the different types and risk factors of phlebitis is crucial for patient care.
Observation:
- Two cases illustrate phlebitis complications: septic thrombophlebitis with Staphylococcus Aureus in an immunocompromised patient and chemical phlebitis in another patient.
- Septic phlebitis, though rare, poses significant risks, while chemical and mechanical phlebitis are more common but generally less severe.
- Identified risk factors for phlebitis include female sex, prior phlebitis episodes, forearm insertion sites, emergency catheter placement, and antibiotic administration.
Findings:
- Randomized controlled trials have not demonstrated benefits from routine replacement of peripheral IV catheters every 72-96 hours.
- A recent Cochrane Review supports replacing peripheral IV catheters based on clinical indication rather than a fixed schedule.
- This shift challenges previous standard practices regarding IV catheter maintenance.
Implications:
- Clinical practice guidelines for IV catheter management should be updated to reflect the latest evidence.
- Focusing on clinical indication for replacement may reduce unnecessary interventions and associated costs.
- Further research may explore optimal strategies for preventing and managing phlebitis in diverse patient populations.
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