Related Experiment Video
Updated: May 28, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
Novel "CHASER" pathway for the management of pericardial disease
Edgar Argulian1, Dan G Halpern, Emad F Aziz
1Department of Medicine, Division of Cardiology, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, NY 10025, USA.
Insights
Managing pericardial disease is challenging due to limited evidence. This study introduces a unified, stepwise pathway using the "CHASER" acronym for diagnosis and a scoring system for pericardial effusion management.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Pericardial disease diagnosis and management present significant clinical challenges.
- The existing evidence base for pericardial diseases is notably limited compared to other cardiac conditions.
Purpose of the Study:
- To outline a unified, stepwise pathway-based approach for managing pericardial disease.
- To provide clinicians with evidence-based guidance for decision-making in pericardial disease therapy.
Main Methods:
- Development of a pathway using the
- CHASER
- acronym for entry points: chest pain, hypotension/arrest, shortness of breath, imaging findings, and right-predominant heart failure.
- Proposal of a scoring system for pericardial effusion assessment, considering etiology, size, and hemodynamic parameters.
- Application of the score to clinically stable patients with pericardial effusion to guide drainage decisions.
Main Results:
- The proposed pathway offers a structured approach to pericardial disease management.
- A novel scoring system aids in quantifying the need for pericardial effusion drainage in stable patients.
Conclusions:
- The stepwise, pathway-based approach aims to standardize and improve patient-tailored, evidence-based management of pericardial disease.
- Further research is needed to validate the feasibility, efficacy, and reliability of this proposed management pathway.
Abstract:
The diagnosis and management of pericardial disease are very challenging for clinicians. The evidence base in this field is relatively scarce compared with other disease entities in cardiology. In this article, we outline a unified, stepwise pathway-based approach for the management of pericardial disease. We used the "CHASER" acronym to define the entry points into the pathway. These include chest pain, hypotension or arrest, shortness of breath, echocardiographic or other imaging finding of pericardial effusion, and right-predominant heart failure. We propose a score for the assessment of pericardial effusion that is composed of the following 3 parameters: the etiology of the effusion, the size of the effusion, and the echocardiographic assessment of hemodynamic parameters. The score is applied to clinically stable patients with pericardial effusion to quantify the necessity of pericardial effusion drainage. A stepwise, pathway-based approach to the management of pericardial disease is intended to provide guidance for clinicians in decision-making and a patient-tailored evidence-based approach to medical and surgical therapy for pericardial disease. The pathway for the management of pericardial disease is the ninth project to be incorporated into the "Advanced Cardiac Admission Program" at Saint Luke's Roosevelt Hospital Center of Columbia University in New York. Further studies should focus on the validation of the feasibility, efficacy, and reliability of this pathway.
Related Concept Videos
Pericarditis III: Medical Management
Pericarditis IV: Nursing Management
Pericarditis I: Introduction
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Myocarditis III: Medical Management
Cardiomyopathy II: Dilated Cardiomyopathy
