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Updated: May 28, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Complications from catheter ablation of atrial fibrillation: a systematic review
Abhishek Maan1, Amir Y Shaikh, Moussa Mansour
1Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Insights
Catheter ablation (CA) for atrial fibrillation (AF) is increasingly used but carries risks. This review details CA complications and evolving strategies to improve safety and efficacy for treating symptomatic AF.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Atrial fibrillation (AF) is the most prevalent clinical arrhythmia.
- Catheter ablation (CA) is a key treatment for symptomatic AF refractory to antiarrhythmic drugs.
- AF ablation complexity necessitates understanding associated procedural risks.
Purpose of the Study:
- To systematically review reported complications of CA for AF.
- To analyze the incidence and types of major and minor complications.
- To explore evolving strategies for mitigating CA risks.
Main Methods:
- Systematic literature review of CA for AF complications.
- Quantification of reported procedural risks.
- Analysis of trends in complication rates and types over time.
Main Results:
- CA for AF is associated with significant procedural risks.
- A spectrum of complications, including life-threatening events, has been documented.
- The review quantifies these risks and identifies patterns.
Conclusions:
- Understanding CA risks is crucial for patient selection and procedural planning.
- Evolving techniques aim to enhance the safety profile of AF ablation.
- Minimizing complications can improve the efficacy of CA for AF treatment.
Abstract:
Atrial fibrillation (AF) is the most common arrhythmia requiring treatment that is encountered in clinical practice. Recent advances in the understanding of underlying mechanisms of AF have led to the increased use of catheter ablation (CA) as a treatment modality for paroxysmal, persistent, or long-standing persistent AF in patients with symptomatic AF despite treatment with antiarrhythmic medications. Because of the complexity in technique and anatomic location of the ablation sites, it is not surprising that CA of AF is associated with a greater risk of procedural complications compared with simpler cardiac ablation procedures. Major and minor complications, including life-threatening complications, have been described and quantified. This systematic review describes the potential risks of CA that have been reported over a period and provides insights into the evolving strategies to minimize these complications, thus making CA techniques safer and potentially more efficacious for AF.
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