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Related Experiment Video

Updated: May 28, 2026

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
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Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

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Poorly differentiated thyroid carcinomas: how much poorly differentiated is needed?

Matthias Dettmer1, Anja Schmitt, Hans Steinert

  • 1Institute of Pathology, University of Bern, Triemlispital, Zürich. dettmerms@upmc.edu

The American Journal of Surgical Pathology
|October 13, 2011
PubMed
Summary
This summary is machine-generated.

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Even small amounts of poorly differentiated (PD) thyroid carcinoma areas (≥10%) significantly worsen patient prognosis. Reporting these PD areas is crucial for accurate thyroid cancer assessment.

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Poorly differentiated (PD) thyroid carcinomas bridge the gap between well-differentiated and anaplastic thyroid carcinomas.
  • Morphologic criteria for PD tumors are established, but the minimum PD area required for diagnosis remains unclear.

Purpose of the Study:

  • To determine the diagnostic threshold for poorly differentiated areas in thyroid carcinomas.
  • To assess the prognostic impact of varying percentages of poorly differentiated areas in thyroid tumors.

Main Methods:

  • Analysis of 42 thyroid carcinoma patients with adverse outcomes and 50 control follicular carcinoma patients.
  • Application of the Turin criteria to identify poorly differentiated areas, including growth patterns, nuclear features, necrosis, and mitotic rate.

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Last Updated: May 28, 2026

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
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Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

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  • Statistical analysis using Kaplan-Meier and multivariate models to evaluate prognostic significance.

    • Main Results:

    • A cutoff of 10% poorly differentiated areas identified 35 PD carcinomas.
    • Thyroid carcinomas with ≥10% PD areas showed significantly worse survival than controls (P<0.001).
    • Poorly differentiated differentiation was the only consistent significant prognostic factor in multivariate analysis.

    Conclusions:

    • Even minimal amounts (≥10%) of poorly differentiated areas in thyroid carcinomas significantly impact prognosis.
    • Reporting the presence of poorly differentiated areas is recommended for accurate thyroid cancer prognostication.