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Updated: May 28, 2026
05:25
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Systematic review of therapy for men with overactive bladder
1Consultant Urological Surgeon, Sheffield Teaching Hospitals NHS Foundation Trust, Department of Urology, The Royal Hallamshire Hospital, Sheffield, UK.
Summary
Men with lower urinary tract symptoms (LUTS) often have benign prostatic hyperplasia (BPH). Standard treatment involves alpha-1-AR antagonists, with combination therapy for persistent storage symptoms.
Area of Science:
- Urology
- Pharmacology
Background:
- Lower urinary tract symptoms (LUTS) in men can stem from various causes.
- Overactive bladder (OAB) is a clinical diagnosis guiding initial management.
- Benign prostatic hyperplasia (BPH) complicates OAB diagnosis in men, being a histological finding.
Purpose of the Study:
- To clarify the management of LUTS in men, particularly concerning OAB and BPH.
- To identify appropriate pharmacologic treatments for men experiencing both voiding and storage LUTS.
Main Methods:
- Review of diagnostic approaches for LUTS in men.
- Evaluation of pharmacologic treatment strategies for LUTS associated with BPH.
Main Results:
- Storage symptoms are often the most bothersome LUTS in men with BPH.
- Current treatment often focuses on BPH rather than OAB-specific medications.
- Alpha-1-AR antagonists are the standard pharmacologic treatment for men with bothersome voiding and storage LUTS at low risk of progression.
Conclusions:
- Alpha-1-AR antagonists are the recommended first-line pharmacologic treatment for LUTS in men with BPH.
- Combination therapy with an alpha-1-AR antagonist and an antimuscarinic agent is effective for persistent storage symptoms in men with voiding LUTS.
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