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Related Experiment Video

Updated: May 28, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Treating overactive bladder in the elderly.

¹Division of Geriatric Medicine, Department of Medicine, University of Alberta, Edmonton, AB.

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada

|October 13, 2011

Summary

This summary is machine-generated.

Overactive bladder (OAB) is more common and severe in older adults, often requiring higher medication doses. Newer antimuscarinic drugs are safe for cognitively intact older individuals with OAB.

Related Experiment Videos

Last Updated: May 28, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Area of Science:

Gerontology
Urology
Pharmacology

Background:

Overactive bladder (OAB) prevalence and symptom severity increase with age.
Older adults are more likely to seek medication for bladder issues and require higher doses.

Purpose of the Study:

To evaluate the efficacy and safety of OAB treatments in older populations.
To address concerns regarding cognitive side effects of antimuscarinic agents in the elderly.

Main Methods:

Review of conventional OAB treatments including conservative, lifestyle, and pharmacotherapy.
Analysis of antimuscarinic pharmacotherapy, focusing on newer agents and cognitive safety.

Main Results:

Conventional OAB treatments combined with antimuscarinic pharmacotherapy are effective in older individuals.
Newer antimuscarinic agents demonstrate cognitive safety in cognitively intact older patients.

Conclusions:

OAB treatment strategies combining lifestyle modifications and newer antimuscarinics are effective and safe for the aging population.
Cognitive safety of newer antimuscarinics supports their use in older adults with OAB.